Your resume is still one of the most critical tools of a job search. A lot of resumes I see are full of responsibilities (instead of tangible achievements) and jobseekers send the same resume to various openings. One of my best tips for finding a new job is to have an achievement-oriented resume that includes quantifiable achievements that are relevant to the job you're applying for.
Make yourself an obvious fit. Study the words and phrases that are used in the job description. Make sure you include them in your resume (provided you have that experience, of course). Tailor your resume to each job – the recruiter should know within a few seconds of looking at your resume that you have the skills they are looking for.